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Article

Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors.

Scientific reports - 8 Sept 2020

Sakamaki Keiichi, Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro, Goto Hidemi

Abstract excerpt

Although the majority of gastrointestinal stromal tumors (GISTs) possess KIT mutations that induce constitutive signal transduction, the clinical outcomes are variable. The ETS translocation variant 1 (ETV1) gene encodes a transcription factor that is reported to cooperate with KIT in GISTs. However, the clinical role of ETV1 is largely unknown. The aim of this study was to examine ETV1 expression and its...

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Identifiers

PMID: 32901065
DOI: 10.1038/s41598-020-71719-y
PMCID: PMC7478956

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