Article
Heterozygous retinoblastoma gene mutation compromises in vitro osteogenesis of adipose mesenchymal stem cells - a temporal gene expression study.
Experimental cell research - 1 Nov 2020
Vincent Ambily, Natarajan Viswanathan, Khetan Vikas, Krishnakumar Subramanian, Parameswaran Sowmya
Abstract excerpt
Osteosarcoma (OS) is a bone malignancy affecting children and adolescents. Retinoblastoma (RB) patients with germline RB1 mutations are susceptible to osteosarcoma in the second decade of their life. Several studies, particularly in mice, have revealed a role for RB1 in osteogenesis. Since, there is species specific difference attributed in retinoblastoma tumorigenesis between mice and human, we assumed, it is...
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