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Inhibition of Osteogenic Differentiation of Human Adipose‐Derived Stromal Cells by Retinoblastoma Binding Protein 2 Repression of RUNX2‐Activated Transcription

20 May 2011

Abstract excerpt

Histone methylation is regarded as an important type of histone modification defining the epigenetic program during the lineage differentiation of stem cells. A better understanding of this epigenetic mechanism that governs osteogenic differentiation of human adipose-derived stromal cells (hASCs) can improve bone tissue engineering and provide new insights into the modulation of hASC-based cell therapy....

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PMID: 21604327
DOI: 10.1002/stem.663

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