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Article

Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis.

Human immunology - 1 Dec 2020

Potaczek Daniel P, Przytulska-Szczerbik Aleksandra, Bazan-Socha Stanisława, Nastałek Magdalena, Wojas-Pelc Anna, Okumura Ko, Nishiyama Chiharu, Jurczyszyn Artur, Undas Anetta, Wypasek Ewa

Abstract excerpt

Dendritic cell toll-like receptors (TLRs) and the high-affinity immunoglobulin E (IgE) receptor (FcεRI) may biologically interact with regard to atopic dermatitis (AD) development and, especially, severity. Our aim here was to test if such interaction can be detected on the genetic level. The combined effect of the TLR2 gene (TLR2) rs4696480 and the FcεRI α-chain gene (FCER1A) rs2252226 and rs2251746...

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PMID: 32883546
DOI: 10.1016/j.humimm.2020.08.002

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