Article
Oxaliplatin-induced haematological toxicity and splenomegaly in mice.
PloS one - 1 Jan 2020
Lees Justin G, White Daniel, Keating Brooke A, Barkl-Luke Mallory E, Makker Preet G S, Goldstein David, Moalem-Taylor Gila
Abstract excerpt
PURPOSE: Haematological toxicities occur in patients receiving oxaliplatin. Mild anaemia (grade 1-2) is a common side effect and approximately 90% of recipients develop measurable spleen enlargement. Although generally asymptomatic, oxaliplatin-induced splenomegaly is independently associated with complications following liver resection for colorectal liver metastasis and separately with poorer patient outcomes....
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