Article
Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population.
Psychiatric genetics - 1 Oct 2020
Lv Ye, Sun Yang, Dai Di, Luan Zhi-Lin, Lu He-Yuan, Li Cheng-Jie, Luo Yi-Yang
Abstract excerpt
As a severely and highly heritable psychotic disorder, schizophrenia has become a serious public health problem in modern society. Pleiotrophin (PTN) is a secreted cell cytokine associated with the extracellular matrix and acts as a growth factor. PTN is mainly expressed in neuroectodermal and mesodermal tissues, indicating its effect in neuron migration and epithelium-mesenchyme interactions. Whereas PTN is...
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