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Article

Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis.

Journal of the American Chemical Society - 23 Sept 2020

Fullenkamp Christopher R, Hsu Yen-Pang, Quardokus Ellen M, Zhao Gengxiang, Bewley Carole A, VanNieuwenhze Michael, Sulikowski Gary A

Abstract excerpt

Chrysophaentin A is an antimicrobial natural product isolated from the marine alga C. taylori in milligram quantity. Structurally, chrysophaentin A features a macrocyclic biaryl ether core incorporating two trisubstituted chloroalkenes at its periphery. A concise synthesis of iso- and 9-dechlorochrysophaentin A enabled by a Z-selective ring-closing metathesis (RCM) cyclization followed by an oxygen to carbon ring...

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Identifiers

PMID: 32866011
DOI: 10.1021/jacs.0c04917
PMCID: PMC7771388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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