Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modifiers in rare disorders: the case of fragile X syndrome.

European journal of human genetics : EJHG - 1 Jan 2021

Crawford Hayley, Scerif Gaia, Wilde Lucy, Beggs Andrew, Stockton Joanne, Sandhu Pria, Shelley Lauren, Oliver Chris, McCleery Joseph

Abstract excerpt

Methods employed in genome-wide association studies are not feasible ways to explore genotype-phenotype associations in rare disorders due to limited statistical power. An alternative approach is to examine relationships among specific single nucleotide polymorphisms (SNPs), selected a priori, and behavioural characteristics. Here, we adopt this strategy to examine relationships between three SNPs (5-HTTLPR,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Fragile X Syndrome

Share to Genes, Modifier

Share to Monoamine Oxidase

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32862204
DOI: 10.1038/s41431-020-00711-x
PMCID: PMC7852869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modifiers in rare disorders: the case of fragile X syndrome.PMID 32862204Read ↗

Genetic determinants of longitudinal behavioural trajectories in rare conditions: The case of fragile X syndrome.Semantic proximity Read ↗

Brief report: aggression and stereotypic behavior in males with fragile X syndrome--moderating secondary genes in a "single gene" disorder.Semantic proximity Read ↗

Genetics of impulsive behaviour.Semantic proximity Read ↗

MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene-environment interaction.Semantic proximity Read ↗

Aggressiveness in Italian Children with ADHD: Maoa Gene Polymorphisms InvolvementSemantic proximity Read ↗

MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet.Semantic proximity Read ↗

20 ans après: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition.Semantic proximity Read ↗

The prevalence of aggression in genetic syndromes: a review.Semantic proximity Read ↗

Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.Semantic proximity Read ↗

Assessment of Aggression and Anger Levels in Athletes: A Study on Gene Polymorphisms in Forensic Science.Semantic proximity Read ↗

Harsh discipline, childhood sexual assault, and MAOA genotype: an investigation of main and interactive effects on diverse clinical externalizing outcomes.Semantic proximity Read ↗

The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.