Article
Brief report: aggression and stereotypic behavior in males with fragile X syndrome--moderating secondary genes in a "single gene" disorder.
Journal of autism and developmental disorders - 1 Jan 2008
Hessl David, Tassone Flora, Cordeiro Lisa, Koldewyn Kami, McCormick Carolyn, Green Cherie, Wegelin Jacob, Yuhas Jennifer, Hagerman Randi J
Abstract excerpt
Although fragile X syndrome (FXS) is a single gene disorder with a well-described phenotype, it is not known why some individuals develop more significant maladaptive behaviors such as aggression or autistic symptoms. Here, we studied two candidate genes known to affect mood and aggression, the serotonin transporter (5-HTTLPR) and monoamine oxidase A (MAOA-VNTR) polymorphisms, in 50 males with FXS ages 8-24...
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