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Article

Genetic determinants of longitudinal behavioural trajectories in rare conditions: The case of fragile X syndrome.

Behavioural brain research - 8 May 2025

Cartwright Lydia, Scerif Gaia, Oliver Chris, Beggs Andrew, Stockton Joanne, Wilde Lucy, Crawford Hayley

Abstract excerpt

Despite being a monogenic condition, individual variability in the phenotypic profile of fragile X syndrome (FXS) is substantial, with behavioural outcomes differing in severity and frequency. Existing studies have revealed that common variation in 5-HTTLPR (serotonin) and COMT (dopamine) single nucleotide polymorphisms (SNPs) is associated with behavioural variation in FXS when measured cross-sectionally....

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Aggression
Catechol O-Methyltransferase
Fragile X Syndrome
Longitudinal Studies
Monoamine Oxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serotonin Plasma Membrane Transport Proteins

Stereotyped Behavior

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Identifiers

PMID: 40054504
DOI: 10.1016/j.bbr.2025.115527

Genes

COMT
MAOA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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