Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube, and Primary Peritoneal Cancers: A Multi-Institutional Study.

doi:10.31557/APJCP.2020.21.8.2381

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Article

Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube, and Primary Peritoneal Cancers: A Multi-Institutional Study.

Asian Pacific journal of cancer prevention : APJCP - 1 Aug 2020

Lertkhachonsuk Arb-Aroon, Suprasert Prapaporn, Manchana Tarinee, Kittisiam Thannaporn, Kantathavorn Nuttavut, Chansoon Tharintorn, Khunamornpong Surapan, Pohthipornthawat Natkrita, Tangjitgamol Siriwan, Luasiripanthu Taksa, Teerapakpinyo Chinachote, Shuangshot Shanop, Iemwimangsa Nareenart, Chantratita Wasun

Abstract excerpt

BACKGROUND AND OBJECTIVE: Ovarian, fallopian tube, or primary peritoneal cancer patients with BRCA gene mutation have enhanced sensitivity to platinum-based regimens and PARP inhibitors. However, the knowledge regarding BRCA mutation in Thai patients is limited. This study aimed at identifying the prevalence and characteristics of somatic and germline BRCA 1 and 2 mutations in Thai patients with these cancers....

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PMID: 32856869
DOI: 10.31557/APJCP.2020.21.8.2381
PMCID: PMC7771940

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