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Article

Effect of Gene Mutation on Seizures in Surgery for Tuberous Sclerosis Complex.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 May 2021

Chivukula Srinivas, Modiri Omeed, Kashanian Alon, Babayan Diana, Ibrahim George M, Weil Alexander G, Tu Albert, Wu Joyce Y, Mathern Gary W, Fallah Aria

Abstract excerpt

BACKGROUND: Tuberous sclerosis complex (TSC) is a rare genetic disorder that commonly leads to drug-resistant epilepsy in affected patients. This study aimed to determine whether the underlying genetic mutation (TSC1 vs. TSC2) predicts seizure outcomes following surgical treatments for epilepsy. METHODS: We retrospectively assessed TSC patients using the TSC Natural History Database core registry. Data review...

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Identifiers

PMID: 32854808
DOI: 10.1017/cjn.2020.185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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