Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial.

doi:10.1016/j.pediatrneurol.2024.06.012

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Article

Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial.

Pediatric neurology - 1 Oct 2024

Farach Laura S, Richard Melissa A, Wulsin Aynara C, Bebin Elizabeth M, Krueger Darcy A, Sahin Mustafa, Porter Brenda E, McPherson Tarrant O, Peters Jurriaan M, O'Kelley Sarah, Taub Katherine S, Rajaraman Rajsekar, Randle Stephanie C, McClintock William M, Koenig Mary Kay, Frost Michael D, Werner Klaus, Nolan Danielle A, Wong Michael, Cutter Gary, Northrup Hope, Au Kit Sing

Abstract excerpt

BACKGROUND: Children with tuberous sclerosis complex (TSC) are at high risk for drug-resistant epilepsy (DRE). The ability to stratify those at highest risk for DRE is important for counseling and prompt, aggressive management, necessary to optimize neurocognitive outcomes. Using the extensively phenotyped PREVeNT cohort, we aimed to characterize whether the TSC genotype was associated with DRE. METHODS: The...

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Identifiers

PMID: 39142021
DOI: 10.1016/j.pediatrneurol.2024.06.012
PMCID: PMC12854254

Genes

TSC2
TSC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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