Article
Do germline genetic variants influence surgical outcomes in drug-resistant epilepsy?
Epilepsy research - 1 Oct 2024
Marques Paula, Moloney Patrick B, Ji Caihong, Zulfiqar Ali Quratulain, Ramesh Archana, Goldstein David B, Barboza Karen, Chandran Ilakkiah, Rong Marlene, Selvarajah Arunan, Qaiser Farah, Lira Victor S T, Valiante Taufik A, Bazil Carl W, Choi Hyunmi, Devinsky Orrin, Depondt Chantal, O'Brien Terence, Perucca Piero, Sen Arjune, Dugan Patricia, Sands Tristan T, Delanty Norman, Andrade Danielle M
Abstract excerpt
OBJECTIVE: We retrospectively explored patients with drug-resistant epilepsy (DRE) who previously underwent presurgical evaluation to identify correlations between surgical outcomes and pathogenic variants in epilepsy genes. METHODS: Through an international collaboration, we evaluated adult DRE patients who were screened for surgical candidacy. Patients with pathogenic (P) or likely pathogenic (LP) germline...
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