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Article

Management of epilepsy in tuberous sclerosis complex

1 Mar 2008

Abstract excerpt

Tuberous sclerosis complex (TSC) is an inherited disorder resulting from mutations in one of two genes, TSC1 (Hamartin) and TSC2 (Tuberin). These two proteins form a cytosolic complex that inhibits the mTOR pathway that controls cell growth and proliferation. Pathologically, abnormalities of neuronal migration, cellular differentiation and excessive cellular proliferation all contribute to the formation of the...

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PMID: 18345974
DOI: 10.1586/14737175.8.3.457

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