Article
Methylome-wide association study of first-episode schizophrenia reveals a hypermethylated CpG site in the promoter region of the TNIK susceptibility gene.
Progress in neuro-psychopharmacology & biological psychiatry - 2 Mar 2021
Nie Fa-Yi, Zhang Miao-Ran, Shang Shan-Shan, Zhang Qiao-Xia, Zhang Rui, Chen Peng, Ma Jie
Abstract excerpt
Accumulating evidence suggests that epigenetics plays an important role in the etiology of schizophrenia. Here, we performed a methylome-wide association study (MWAS) of first-onset schizophrenia patients and controls from the Han Chinese population using microarray technology. The DNA methylation profiles revealed 4494 differentially methylated CpG sites. Gene ontology (GO) analysis showed that the functions of...
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