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Article

Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway

30 Jul 2020

Abstract excerpt

Bone metastasis (BM) dramatically reduces the quality of life and life expectancy in lung adenocarcinoma (LUAD) patients. There is an urgent need to identify potential biomarkers for application in the treatment of this deadly disease. We compared patient BM, LUAD, and para-LUAD tissues using proteomic analysis and identified Aldehyde Dehydrogenase 2 (ALDH2), which can detoxify acetaldehyde to acetic acid, as one...

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Identifiers

PMID: 32850324
DOI: 10.3389/fonc.2020.01141

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