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Article

Relationship between smoking and ALS: Mendelian randomisation interrogation of causality.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2020

Opie-Martin Sarah, Wootton Robyn E, Budu-Aggrey Ashley, Shatunov Aleksey, Jones Ashley R, Iacoangeli Alfredo, Al Khleifat Ahmad, Davey-Smith George, Al-Chalabi Ammar

Abstract excerpt

OBJECTIVE: Smoking has been widely studied as a susceptibility factor for amyotrophic lateral sclerosis (ALS), but results are conflicting and at risk of confounding bias. We used the results of recently published large genome-wide association studies and Mendelian randomisation methods to reduce confounding to assess the relationship between smoking and ALS. METHODS: Two genome-wide association studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32848012
DOI: 10.1136/jnnp-2020-323316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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