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From low to high pathogenicity-Characterization of H7N7 avian influenza viruses in two epidemiologically linked outbreaks.

Transboundary and emerging diseases - 1 Dec 2018

Dietze Klaas, Graaf Annika, Homeier-Bachmann Timo, Grund Christian, Forth Leonie, Pohlmann Anne, Jeske Christa, Wintermann Mattis, Beer Martin, Conraths Franz J, Harder Timm

Abstract excerpt

The ability of low pathogenic (LP) avian influenza viruses (AIV) of the subtypes H5 and H7 to mutate spontaneously to highly pathogenic (HP) variants is the main reason for their stringent control. On-the-spot evidence from the field of mutations in LPAIV to render the virus into nascent HP variants is scarce. Epidemiological investigations and molecular characterization of two spatiotemporally linked outbreaks...

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PMID: 29790657
DOI: 10.1111/tbed.12906

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