Article
Mesenchymal progenitor cells in perivascular niches: forerunners of mesenchymal stem cells and players in tissue scarring and regeneration.
Vascular pharmacology - 1 Dec 2025
Thottapillil Neelima, Corselli Mirko, Murray Ian, Hardy Reef, Gomez-Salazar Mario, Casamitjana Joan, Shaw Isaac, Wang Ziyi, Vezzani Bianca, Ding Lijun, Deneka Alexander, Guo Yuyuan, Giacovazzi Stefania, Crisan Mihaela, James Aaron, Péault Bruno
Abstract excerpt
The walls of all embryonic, foetal, and adult blood vessels contain mesodermal progenitors, distributed as pericytes in capillaries and micro vessels, and fibroblastic cells in the tunica adventitia of larger veins and arteries. Following dissociation, selection by flow cytometry, and culture, those perivascular cells turn into bona fide mesenchymal stem cells of which they possess all attributes. In vivo, the...
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