Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).

doi:10.1002/gps.5409

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).

International journal of geriatric psychiatry - 1 Jan 2021

Rodriguez Francisca S, Roehr Susanne, Pabst Alexander, Kleineidam Luca, Fuchs Angela, Wiese Birgitt, Lühmann Dagmar, Brettschneider Christian, Wolfsgruber Steffen, Pentzek Michael, van den Bussche Hendrik, König Hans-Helmut, Weyerer Siegfried, Werle Jochen, Bickel Horst, Weeg Dagmar, Maier Wolfgang, Scherer Martin, Wagner Michael, Riedel-Heller Steffi G

Abstract excerpt

OBJECTIVES: Previous studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Cognition

Share to Cognitive Dysfunction

Share to Dementia

Share to Language

Share to Primary Health Care

Source

Open in PubMed

Identifiers

PMID: 32819031
DOI: 10.1002/gps.5409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).PMID 32819031Read ↗

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.Semantic proximity Read ↗

Impact of work type and APOE-e4 status on cognitive functioning in older women.Semantic proximity Read ↗

APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-Adult-study.Semantic proximity Read ↗

Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for InterventionsSemantic proximity Read ↗

Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease.Semantic proximity Read ↗

Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer's disease.Semantic proximity Read ↗

Genome-wide association study of occupational attainment as a proxy for cognitive reserve.Semantic proximity Read ↗

Problems meeting basic needs moderate the association between the APOE epsilon4 allele and cognitive decline.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene-environment interaction for the risk of dementia and Alzheimer's disease dementia.Semantic proximity Read ↗

Stress, race, and APOE: understanding the interplay of risk factors for changes in cognitive functioning.Semantic proximity Read ↗

Stressful events, social support, and cognitive function in middle-aged adults with a family history of Alzheimer's disease.Semantic proximity Read ↗

Different risk and protective factors predict change of planning ability in middle versus older age.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.