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Article

Clinical activity of pembrolizumab in metastatic prostate cancer with microsatellite instability high (MSI-H) detected by circulating tumor DNA.

Journal for immunotherapy of cancer - 1 Aug 2020

Barata Pedro, Agarwal Neeraj, Nussenzveig Roberto, Gerendash Benjamin, Jaeger Ellen, Hatton Whitley, Ledet Elisa, Lewis Brian, Layton Jodi, Babiker Hani, Bryce Alan, Garje Rohan, Stein Cy, Kiedrowski Lesli, Saylor Philip, Sartor Oliver

Abstract excerpt

To report a multi-institutional case series of patients with advanced microsatellite instability high (MSI-H) prostate adenocarcinoma identified with clinical cell-free DNA (cfDNA) next-generation sequencing (NGS) testing and treated with immune checkpoint inhibitors. Retrospective analysis of patients with metastatic castration-resistant prostate cancer (mCRPC) and MSI-H tumor detected by a commercially...

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Share to Antibodies, Monoclonal, Humanized
Share to Antineoplastic Agents, Immunological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Coronavirus Infections

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Source

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Identifiers

PMID: 32788235
DOI: 10.1136/jitc-2020-001065
PMCID: PMC7422632

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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