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BReast CAncer (BRCA) gene mutations as an emerging biomarker for the treatment of gastrointestinal malignancies.

Chinese clinical oncology - 1 Oct 2020

Premnath Naveen, O'Reilly Eileen M

Abstract excerpt

BReast CAncer (BRCA) genes 1 and 2 were discovered in the 1990's by Hall et al. and Wooster et al. respectively. BRCA genes have been shown to be associated with an increased risk of various gastrointestinal (GI) cancers beyond known risk of breast, ovary and prostate cancers. Studies have demonstrated the role of BRCA genes in the DNA repair pathway and modalities to exploit this pathway are being currently...

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PMID: 32787343
DOI: 10.21037/cco-2019-ddp-05

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