The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.

doi:10.1186/s13059-020-02115-y

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Article

The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.

Genome biology - 6 Aug 2020

Kosti Adam, de Araujo Patricia Rosa, Li Wei-Qing, Guardia Gabriela D A, Chiou Jennifer, Yi Caihong, Ray Debashish, Meliso Fabiana, Li Yi-Ming, Delambre Talia, Qiao Mei, Burns Suzanne S, Lorbeer Franziska K, Georgi Fanny, Flosbach Markus, Klinnert Sarah, Jenseit Anne, Lei Xiufen, Sandoval Carolina Romero, Ha Kevin, Zheng Hong, Pandey Renu, Gruslova Aleksandra, Gupta Yogesh K, Brenner Andrew, Kokovay Erzsebet, Hughes Timothy R, Morris Quaid D, Galante Pedro A F, Tiziani Stefano, Penalva Luiz O F

Abstract excerpt

BACKGROUND: RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for targeted therapy. RESULTS: We identify the RNA-binding protein...

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PMID: 32762776
DOI: 10.1186/s13059-020-02115-y
PMCID: PMC7412812

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