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Article

An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report.

Journal of medical case reports - 7 Aug 2020

Miyazaki Shinichi, Kuno Yasumasa, Hayai Shunsaku, Teramachi Ryo, Yamashita Ryo, Saito Yusuke, Higuchi Kosuke, Nara Yoshiharu, Ikeda Takuya

Abstract excerpt

BACKGROUND: Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor-sensitizing and T790M resistance mutations. Almost all patients who initially respond to an epidermal growth factor receptor tyrosine kinase inhibitor subsequently report disease progression. Epidermal growth factor...

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Identifiers

PMID: 32762742
DOI: 10.1186/s13256-020-02447-0
PMCID: PMC7412784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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