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Article

Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.

Bioorganic & medicinal chemistry letters - 15 Sept 2020

Engers Darren W, Bollinger Sean R, Felts Andrew S, Vadukoot Anish K, Williams Charles H, Blobaum Anna L, Lindsley Craig W, Hong Charles C, Hopkins Corey R

Abstract excerpt

The activin-like kinases are a family of kinases that play important roles in a variety of disease states. Of this class of kinases, ALK2, has been shown by a gain-of-function to be the primary driver of the childhood skeletal disease fibrodysplasia ossificans progressiva (FOP) and more recently the pediatric cancer diffuse intrinsic pontine glioma (DIPG). Herein, we report our efforts to identify a novel...

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Identifiers

PMID: 32750526
DOI: 10.1016/j.bmcl.2020.127418
PMCID: PMC7494637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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