Development and validation of a universal blood donor genotyping platform: a multinational prospective study.

doi:10.1182/bloodadvances.2020001894

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Article

Development and validation of a universal blood donor genotyping platform: a multinational prospective study.

Blood advances - 11 Aug 2020

Gleadall Nicholas S, Veldhuisen Barbera, Gollub Jeremy, Butterworth Adam S, Ord John, Penkett Christopher J, Timmer Tiffany C, Sauer Carolin M, van der Bolt Nieke, Brown Colin, Brugger Kim, Dilthey Alexander T, Duarte Daniel, Grimsley Shane, van den Hurk Katja, Jongerius John M, Luken Jessie, Megy Karyn, Miflin Gail, Nelson Christopher S, Prinsze Femmeke J, Sambrook Jennifer, Simeoni Ilenia, Sweeting Michael, Thornton Nicole, Trompeter Sara, Tuna Salih, Varma Ram, Walker Matthew R, Danesh John, Roberts David J, Ouwehand Willem H, Stirrups Kathleen E, Rendon Augusto, Westhoff Connie M, Di Angelantonio Emanuele, van der Schoot C Ellen, Astle William J, Watkins Nicholas A, Lane William J

Abstract excerpt

Each year, blood transfusions save millions of lives. However, under current blood-matching practices, sensitization to non-self-antigens is an unavoidable adverse side effect of transfusion. We describe a universal donor typing platform that could be adopted by blood services worldwide to facilitate a universal extended blood-matching policy and reduce sensitization rates. This DNA-based test is capable of...

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PMID: 32750130
DOI: 10.1182/bloodadvances.2020001894
PMCID: PMC7422129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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