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Article

Extracellular magnesium and calcium reduce myotonia in ClC-1 inhibited rat muscle.

Neuromuscular disorders : NMD - 1 Jun 2013

Skov Martin, Riisager Anders, Fraser James A, Nielsen Ole B, Pedersen Thomas H

Abstract excerpt

Loss-of-function mutations in the ClC-1 Cl(-) channel trigger skeletal muscle hyperexcitability in myotonia congenita. For reasons that remain unclear, the severity of the myotonic symptoms can vary markedly even among patients with identical ClC-1 mutations, and may become exacerbated during pregnancy and with diuretic treatment. Since both these conditions are associated with hypomagnesemia and hypocalcemia, we...

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Source

Identifiers

PMID: 23623567
DOI: 10.1016/j.nmd.2013.03.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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