Article
A mutation found in esophageal cancer alters integrin β4 mRNA splicing.
Biochemical and biophysical research communications - 27 Aug 2020
Kelly Gabriel T, Faraj Reem, Dai Zhiyu, Cress Anne E, Wang Ting
Abstract excerpt
Integrin β4 (CD104, mRNA: ITGβ4) contributes to anchoring cells to the extracellular matrix and is regulated in many cancer types where it contributes to tumor progression. One splice variant, integrin β4E, is poorly characterized. We extracted several mutations from tumor samples within ITGB4 near the splice site that controls ITGβ4E production, and computational analysis predicted six of these would alter...
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