Article
ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data.
Radiation oncology (London, England) - 31 Jul 2020
Kim Nalee, Kim Se Hoon, Kang Seok-Gu, Moon Ju Hyung, Cho Jaeho, Suh Chang-Ok, In Yoon Hong, Chang Jong Hee
Abstract excerpt
BACKGROUND: To identify the association between somatic ataxia-telangiectasia mutated (ATM) mutations and improved radio-sensitivity, we retrospectively reviewed next-generation sequencing data from patients diagnosed with isocitrate dehydrogenase (IDH)-wildtype high-grade glioma. METHODS: We included 39 individuals with (IDH)-wildtype high-grade glioma (diffuse astrocytoma n = 2, anaplastic astrocytoma n = 10,...
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