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Article

Further enhancement of FR901469 productivity by co-overexpression of cpcA, a cross-pathway control gene, and frbF in fungal sp. No. 11243.

Journal of bioscience and bioengineering - 1 Jul 2017

Matsui Makoto, Yokoyama Tatsuya, Nemoto Kaoru, Kumagai Toshitaka, Tamano Koichi, Machida Masayuki, Shibata Takashi

Abstract excerpt

FR901469 is a secondary metabolite with antifungal activity, produced by fungal sp. No. 11243. In our previous study, we constructed the frbF overexpression mutant (TFH2-2) from the wild-type strain. FR901469 productivity of TFH2-2 was 3.4 times higher than that of the wild-type strain. To further enhance FR901469 productivity in TFH2-2, we attempted to find genes from the genome that limited the productivity as...

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PMID: 28341398
DOI: 10.1016/j.jbiosc.2017.02.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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