Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Alpha-1 Antitrypsin Polymer Load Correlates With Hepatocyte Senescence, Fibrosis Stage and Liver-Related Mortality

1 Jan 2020

Abstract excerpt

BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is an important, inherited cause of chronic liver disease. Marked variation in fibrosis stages in patients with homozygous deficiency and those factors that determine whether heterozygous carriers develop liver fibrosis, remain unexplained. Murine studies implicate polymerized alpha-1 antitrypsin (AAT) within hepatocytes as pathogenic. AIMS AND METHODS: The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to Protease and Inhibitor Mechanisms
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32726073
DOI: 10.15326/jcopdf.7.3.2019.0158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Alpha-1 Antitrypsin Polymer Load Correlates With Hepatocyte Senescence, Fibrosis Stage and Liver-Related MortalityPMID 32726073Read ↗

Quantitative measurement of the histological features of alpha-1 antitrypsin deficiency-associated liver disease in biopsy specimens.Semantic proximity Read ↗

Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver DiseaseSemantic proximity Read ↗

Novel Transgenic Humanized Alpha-1 Antitrypsin Deficiency Mouse Model on Murine <i>SERPINA1</i> Null BackgroundSemantic proximity Read ↗

Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease.Semantic proximity Read ↗

Alpha1-antitrypsin deficiency. 4: Molecular pathophysiology.Semantic proximity Read ↗

Both terminal misfolding and polymerisation contribute to disease-relevant responses in cell models of α <sub>1</sub> -antitrypsin deficiency-associated liver diseaseSemantic proximity Read ↗

Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver diseaseSemantic proximity Read ↗

Z-AAT impairs organelle homeostasis and reduces adaptive response to lipids in alpha-1 antitrypsin deficiency modelsSemantic proximity Read ↗

The proteomic landscape of proteotoxic stress in a fibrogenic liver diseaseSemantic proximity Read ↗

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiencySemantic proximity Read ↗

Longitudinal Evaluation of Individuals With Severe Alpha-1 Antitrypsin Deficiency (Pi∗ZZ Genotype).Semantic proximity Read ↗

Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.