Article
Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations.
Scientific reports - 28 Jul 2020
Cideciyan Artur V, Jacobson Samuel G, Roman Alejandro J, Sumaroka Alexander, Wu Vivian, Charng Jason, Lisi Brianna, Swider Malgorzata, Aguirre Gustavo D, Beltran William A
Abstract excerpt
A common inherited retinal disease is caused by mutations in RHO expressed in rod photoreceptors that provide vision in dim ambient light. Approximately half of all RHO mutations result in a Class B phenotype where mutant rods are retained in some retinal regions but show severe degeneration in other regions. We determined the natural history of dysfunction and degeneration of retained rods by serially evaluating...
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