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CYP1A1 and GSTs common gene variations and presbycusis risk: a genetic association analysis and a bioinformatics approach.

Environmental science and pollution research international - 1 Dec 2020

Karimian Mohammad, Behjati Mohaddeseh, Barati Erfaneh, Ehteram Tayyebeh, Karimian Ali

Abstract excerpt

Antioxidant enzymes such as glutathione S-transferases (GSTs) and cytochromes P450 (CYPs) are involved in the metabolism and detoxification of cytotoxic compounds, as well as the elimination of reactive oxygen species (ROS). Therefore, alterations in the structure of these enzymes could result in prolonged production of ROS with subsequent risk of development of disorders such as presbycusis. This study aimed to...

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PMID: 32712936
DOI: 10.1007/s11356-020-10144-0

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