The Dosage Effect of Manganese Superoxide Dismutase (MnSOD Val16Ala) Polymorphism in Acne Vulgaris and In Silico Identification Analysis of Biological Features of Variation.

Abstract excerpt

The exact cause of acne vulgaris remains unclear. However, evidence suggests polymorphism in the manganese superoxide dismutase (MnSOD) gene increases acne vulgaris risk by altering the protein's secondary structure. This study aimed to perform in silico and in vitro analyses of the MnSOD Val16Ala substitution, involving 119 acne vulgaris patients and 96 controls. Bioinformatic tools, including SIFT, PolyPhen,...

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