Article
Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records.
BMC medical genomics - 25 Jul 2020
Veatch Olivia J, Bauer Christopher R, Keenan Brendan T, Josyula Navya S, Mazzotti Diego R, Bagai Kanika, Malow Beth A, Robishaw Janet D, Pack Allan I, Pendergrass Sarah A
Abstract excerpt
BACKGROUND: Obstructive sleep apnea (OSA) is defined by frequent episodes of reduced or complete cessation of airflow during sleep and is linked to negative health outcomes. Understanding the genetic factors influencing expression of OSA may lead to new treatment strategies. Electronic health records (EHRs) can be leveraged to both validate previously reported OSA-associated genomic variation and detect novel...
Topics
- Case-Control Studies
- Electronic Health Records
- Ethnicity
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Middle Aged