Article
Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.
American journal of respiratory and critical care medicine - 1 Sept 2025
Tolbert Thomas M, Schmickl Christopher N, Gell Laura K, Keenan Brendan T, Mazzotti Diego R, Op de Beeck Sara, Osman Amal M, Peña-Orbea Cinthya, Sands Scott A, Sofer Tamar, Zinchuk Andrey V, Arnardóttir Erna S, Azarbarzin Ali, Chowdhuri Susmita, Cistulli Peter A, Jordan Amy S, Luo Yuanming, Patel Sanjay R, Pépin Jean-Louis, Redline Susan, Schwab Richard J, Wellman Andrew, Eckert Danny J
Abstract excerpt
Background: Obstructive sleep apnea (OSA) pathogenesis, clinical manifestations, and consequences vary markedly among patients. Yet OSA heterogeneity goes largely unaddressed in current management pathways, which are characterized by high treatment failure rates of ∼50%. Growing knowledge of OSA pathogenesis has stimulated new lines of investigation for therapies targeted to specific underlying mechanisms or...
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