Article
Practical Laboratory Tools for Monitoring of BCR-ABL1 Transcripts and Tyrosine Kinase (TK) Domain Mutations in Chronic Myeloid Leukemia Patients Undergoing TK Inhibitor Therapy: A Single-Center Experience in Thailand.
Asian Pacific journal of cancer prevention : APJCP - 1 Jul 2020
Limsuwanachot Nittaya, Kongruang Adcharee, Rerkamnuaychoke Budsaba, Singdong Roongrudee, Niparuck Pimjai, Jootar Saengsuree, Siriboonpiputtana Teerapong
Abstract excerpt
OBJECTIVE: The genetic hallmark of CML is known as the appearance of t(9;22)(q34.1;q11.2) (BCR-ABL1) which is present in more than 95% of cases. Here, we demonstrated practical laboratory tools for monitoring of BCR-ABL1 transcripts in chronic myeloid leukemia patients undergoing TK inhibitor therapy. METHODS: Real time quantitative PCR and direct sequencing were performed for monitoring of BCR-ABL1 transcripts...
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