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Article

DNA extraction from fresh and frozen plasma: an alternative for real-time PCR genotyping in pharmacogenetics.

Molecular biology reports - 1 Aug 2020

Cheli Stefania, Napoli Alessandra, Clementi Emilio, Montrasio Cristina

Abstract excerpt

Genomic DNA, extracted from whole blood samples, is a key element for all genotyping workflows. When stored serum or plasma is the only source of DNA available, the main problem to overcome is the low quantity and poor quality of the DNA obtained, irrespective of the isolation procedure applied. The prevalence of artifacts, such as unbalanced amplification of alleles at specific sites (allelic dropout), is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32705507
DOI: 10.1007/s11033-020-05664-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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