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Article

Caffeine intake influences disease activity and clinical phenotype in systemic lupus erythematosus patients.

Lupus - 1 Oct 2020

Orefice Valeria, Ceccarelli Fulvia, Barbati Cristiana, Lucchetti Ramona, Olivieri Giulio, Cipriano Enrica, Natalucci Francesco, Perricone Carlo, Spinelli Francesca Romana, Alessandri Cristiano, Valesini Guido, Conti Fabrizio

Abstract excerpt

OBJECTIVE: Caffeine, one of the most widely consumed products in the world, seems to interact with multiple components of the immune system by acting as a non-specific phosphodiesterase inhibitor. In vitro dose-dependent treatment with caffeine down-regulates mRNA levels of key inflammation-related genes in peripheral blood mononuclear cells. So far, no robust data are available about the possible contribution of...

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PMID: 32703116
DOI: 10.1177/0961203320941920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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