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Article

Variation Screening of Zygote Arrest 1(ZAR1) in Women with Recurrent Zygote Arrest During IVF/ICSI Programs.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2020

Tian Ye, Yang Jie, Peng Yingqian, Chen Tailai, Huang Tao, Zhang Changming, Zhao Han

Abstract excerpt

Human zygote arrest during in vitro culture is rare and the etiology is unclear. The oocyte-specific gene Zar1 plays an essential role in oocyte-embryo transition, and most embryos from Zar1 knockout female mice arrest at the one-cell stage. This study investigates whether maternal ZAR1 gene variations play a role in human zygote arrest. Sequence analysis of ZAR1 was conducted for 47 women with recurrent...

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PMID: 32700283
DOI: 10.1007/s43032-020-00246-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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