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Article

Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization.

Journal of assisted reproduction and genetics - 1 Mar 2018

Yu Mengru, Zhao Han, Chen Tailai, Tian Ye, Li Mei, Wu Keliang, Bian Yuehong, Su Shizhen, Cao Yongzhi, Ning Yunna, Liu Hongbin, Chen Zi-Jiang

Abstract excerpt

PURPOSE: The etiology of fertilization failure and polyspermy during assisted reproductive technology (ART) remains elusive. The aim of this study was to determine whether mutations in the IZUMO1 receptor (IZUMO1R) gene, which is essential for mammalian fertilization, contribute to the pathogenesis of fertilization failure or polyspermy in humans. METHODS: We recruited 215 female subjects with fertilization...

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Identifiers

PMID: 29243140
DOI: 10.1007/s10815-017-1101-5
PMCID: PMC5904069

Genes

IZUMO1

Provenance

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