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Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

22 Jul 2020

Abstract excerpt

Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have shown the therapeutic potential effect of MSC or their derived products. However, the functional heterogeneity of MSC constitutes an important barrier for transferring these capabilities to the clinic. MSC heterogeneity depends on their origin (biological niche) or the conditions of potential donors (age, diseases or unknown...

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PMID: 32699947
DOI: 10.1007/s00018-020-03600-0

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