Article
Development and validation of a CTNNB1-associated metabolic prognostic model for hepatocellular carcinoma.
Journal of cellular and molecular medicine - 1 Jan 2021
Huo Junyu, Wu Liqun, Zang Yunjin
Abstract excerpt
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy closely related to metabolic reprogramming. We investigated how CTNNB1 mutation regulates the HCC metabolic phenotype and thus affects the prognosis of HCC. We obtained the mRNA expression profiles and clinicopathological data from The Cancer Genome Atlas (TCGA), the International Cancer Genomics Consortium (ICGC) and the Gene Expression Omnibus...
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