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Article

Prediction of age at onset in Parkinson's disease using objective specific neuroimaging genetics based on a sparse canonical correlation analysis.

Scientific reports - 15 Jul 2020

Won Ji Hye, Kim Mansu, Youn Jinyoung, Park Hyunjin

Abstract excerpt

The age at onset (AAO) is an important determinant in Parkinson's disease (PD). Neuroimaging genetics is suitable for studying AAO in PD as it jointly analyzes imaging and genetics. We aimed to identify features associated with AAO in PD by applying the objective-specific neuroimaging genetics approach and constructing an AAO prediction model. Our objective-specific neuroimaging genetics extended the sparse...

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Identifiers

PMID: 32669683
DOI: 10.1038/s41598-020-68301-x
PMCID: PMC7363828

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