Enhanced neuroimaging genetics using multi-view non-negative matrix factorization with sparsity and prior knowledge.

Abstract excerpt

Neuroimaging genetics is a powerful approach to jointly explore genetic features with rich brain imaging phenotypes for neurodegenerative diseases. Conventional imaging genetics approaches based on canonical correlation analysis cannot accommodate multimodal inputs effectively and have limited interpretability. We propose a novel imaging genetics approach based on non-negative matrix factorization (NMF). By...

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