Article
Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis.
The Journal of veterinary medical science - 24 Sept 2020
Tanaka Kazuaki, Yamamoto-Fukuda Misaki, Takizawa Tatsuya, Shimakura Hidekatsu, Sakaguchi Masahiro
Abstract excerpt
Interleukin-4 (IL4) and interleukin-13 (IL13) are involved in the initial response of T helper 2 lymphocytes through the activation of the IL4 receptor alpha (IL4RA), which is a common receptor chain for these cytokines. In humans, several single-nucleotide polymorphisms (SNPs) identified in the IL4R and in interleukin coding genes were associated with atopic disorders. However, the association between canine...
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