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Article

A molecular signature associated with prolonged survival in glioblastoma patients treated with regorafenib

12 Jul 2020

Abstract excerpt

BACKGROUND: Patients with glioblastoma (GBM) have a dramatically poor prognosis. The recent REGOMA trial suggested an overall survival (OS) benefit of regorafenib in recurrent GBM patients. Considering the extreme genetic heterogeneity of GBMs, we aimed to identify molecular biomarkers predictive of differential response to the drug. METHODS: Total RNA was extracted from tumor samples of patients enrolled in the...

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PMID: 32661549
DOI: 10.1093/neuonc/noaa156

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