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MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia

13 Jul 2020

Abstract excerpt

Abstract Aneuploidy occurs within a significant proportion of childhood B-cell acute lymphoblastic leukemia (B-ALL). Some copy number variations (CNV), associated with novel subtypes of childhood B-ALL, have prognostic significance. A total of 233 childhood B-ALL patients were enrolled into this study. Focal copy number alterations of ERG , IKZF1 , PAX5 , ETV6 , RB1 , BTG1 , EBF1 , CDKN2A / 2B , and the...

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PMID: 32661308
DOI: 10.1038/s41598-020-68311-9

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