Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.

doi:10.1016/j.brainres.2020.147013

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Article

Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.

Brain research - 1 Nov 2020

Pulver Aleksander, Kiive Evelyn, Kanarik Margus, Harro Jaanus

Abstract excerpt

Orexins/hypocretins maintain wakefulness, increase appetite and participate in the coordination of stress response. We have recently provided evidence on the role of orexins in aggression, showing the association of the HCRTR1 genotype. (rs2271933 G > A; leading to amino acid substitution Ile408Val) with aggressiveness or breach of law in four independent cohorts. Aggressive behaviour can be reward driven and...

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PMID: 32652147
DOI: 10.1016/j.brainres.2020.147013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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